Bunnie Xo Needed an IV After Weight-Loss Drug Tirzepatide Gave Her 'Diarrhea for Days'

Mar. 15, 2025

Bunnie Xo in Austin in April 2024.Photo:Taylor Hill/WireImage

Taylor Hill/WireImage

Bunnie Xois sharing an update on howshe’s feeling on tirzepatide, joking she’s “never gonna be a sex symbol” because she only makes headlines for “howI wear diapersand s— myself.”

On the Friday, Oct. 25 episode of her podcast,Dumb Blonde.Bunnie, 44, said on the fifth day of taking “Trizeppy" she woke up thinking “I’m gonna have to go to the hospital. Like, I’m so sick,” she said

“By this time, I had diarrhea for days. I was dehydrated so bad.”

“Luckily, we have a nurse on tour with us,” Bunnie, who is on the road with her husband,Jelly Roll, on his ongoingBeautifully Brokentour, said.

Jelly Roll (left) and Bunnie Xo.Gilbert Flores/Penske Media via Getty

Gilbert Flores/Penske Media via Getty

“She gave me two IV bags and some magnesium, and I felt like a new woman. So that right there showed me that I was, like, severely dehydrated. After that, I was fine," she added.

Previously approved to treat diabetes,tirzepatidewas granted FDA approval for weight loss when aclinical trialfound that high doses of tirzepatide helped patients lose an average of 22.5% of their body weight.

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And while Bunnie shared she’s “feeling a little skinny” after having lost 4 lbs., she was quick to point out that she isn’t taking the medication for weight loss.

“I would love to have, you know, about 10 lbs. off of me, but I’m taking it for the inflammation and to regulate my hormones because I believe I have PCOS,” she said.PCOS, or Polycystic Ovary Syndrome is a hormonal disturbance, as theMayo Clinicexplains, where “many small sacs of fluid develop along the outer edge of the ovary.”

As theNational Institute of Healthsays, “Tirzepatide helps with weight reduction and insulin sensitivity, two of the major problems associated with PCOS.”

Stock image of Mounjaro, one of the brand names for tirzepatide.Montinique Monroe/Bloomberg via Getty

Montinique Monroe/Bloomberg via Getty

“I’m doing it for hormone health,” Bunnie said, adding. ”My first time taking it, I took, like … the tiniest bit, and I’m so thankful that I did that because this s— sent me for a ride, dude. I’m still feeling it.”

She cautioned followers about taking the medication, especially “if you’re super sensitive to things like I am and I don’t even wanna take aspirin … I don’t have anything in my system. I’m literally, like, just raw-dogging life over here."

“I take the shot, start feeling like I’m gonna projectile vomit that night.”

But as Bunnie shared, there was one positive side effect: “On Trizeppy, I have been getting, like, eight hours of sleep, and it has been so great.”

“It’s so good. So, that is one positive.”

However, she said, “I still don’t feel great on it.”

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“The scale has gone down. I was 160. I’m now 157.2, and, I’m back to, like, pooping normally in case everybody wants to know. My logs are back.”

But she shared she might be done with taking tirzepatide.

“Everybody tells me it gives them energy, and they feel so good. I just feel like I have a chemical in my body, and I don’t love it. So I think I’m gonna try it one more time.”

“I’m gonna … start really super, super slow, see how that goes. And if that doesn’t work, then I’m done,” she said. “I just can’t do the Trizeppy train.”

source: people.com