Sophia Bush JoinsGrey's AnatomySeason 21, Teases She 'Wasn't Done with My Scrubs'

Mar. 15, 2025

Sophia Bush attends “Melissa Etheridge: My Window” Opening Night at Circle.Photo:Arturo Holmes/Getty Images

Arturo Holmes/Getty Images

Sophia Bushis ready to get her scrubs back on.

The actress, 42, will be joiningGrey’s Anatomyfor the hit show’s 21st season, PEOPLE confirms.

Her character will make her debut in the sixth episode of season 21, which airs Nov. 6, and it’s still unconfirmed whether her character’s husband has been cast yet.

The actress teased her debut onGrey’sin an Instagram post on Oct. 16, as she posted a video of her changing into scrubs inside her trailer.

“I just wasn’t done with my scrubs 💙 @greysabc,” she captioned the post.

This is not Bush’s first foray into the medical procedural world, as she led CBS’sGood Samin 2022. The actress played Dr. Sam Griffith on the show, which ran for only one season, who found herself as the chief of surgery at Detroit’s Lakeshore Sentinel Hospital after her boss fell into a coma.

The series, whichshe called the “best experience” of her careerin an interview withInsiderin 2022, also saw Bush reunite with herOne Tree Hillcostars and friends,Hilarie BurtonandBethany Joy Lenzfor a fun episode whereBurton and Lenz played sisters, and Lenz was seeking treatment at Bush’s character’s hospital.

Sophia Bush in ‘Good Sam’.Danielle Blancher/CBS

Season 21 ofGrey’s Anatomy, which premiered on Sept. 26,is a historic one, as its renewal extended its record as the longest-running primetime medical drama and ABC’s longest-running primetime scripted series.

StarEllen Pompeo, who has played Dr. Meredith Grey throughout the show’s entirety, isslated to appear in seven of the season’s episodes, followinga more scaled-back rolein seasons 19 and 20, PEOPLE confirmed over the summer.

The new season picked up right where season 20 left off, with Meredith (Pompeo) havingresigned from her jobat the hospital after Catherine Fox (Debbie Allen) discovered her secret Alzheimer’s research. Teddy Altman (Kim Raver), Amelia Shepherd (Caterina Scorsone) and Owen Hunt (Kevin McKidd) were also caught in the crosshairs of the controversy.

Adelaide Kane, Midori Francis, Chandra Wilson, Alexis Floyd and Kali Rocha in ‘Grey’s Anatomy’ season 21.Ser Baffo/disney

Ser Baffo/disney

Showrunner Meg Marinis told PEOPLE ahead of the season 21 premiere that"a lot is hanging in the balance" this season.

“Everyone’s jobs are on the line and on top of that, they’re all grappling with various challenges in their personal lives,” she said. “I’m excited for fans to see how that all plays out for each of them. As for Meredith, even though she’s had good intentions, she’s crossed a line with Catherine and there will be consequences as a result.”

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Grey’sAnatomyairs Thursdays at 10 p.m. ET on ABC.

source: people.com